Apimeds Pharmaceuticals

The global leader in therapeutic application of purified venom of the Apis mellifera for inflammatory conditions

Introducing APITOX™

In Phase 3, Apitox demonstrated clinically significant reduction in pain associated with inflammation for Osteoarthritis patients. Apimeds now prepares Apitox for its Phase 3 program in Multiple Sclerosis, affecting inflammatory response with the goal of reducing pain and improving quality of life for patients.

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What is
Apitox


Venom from the honeybee, Apis Mellifera, is composed of 36 fractions many of which all have a physiologic effect. The largest fraction, melittin, comprising of over 50% of the Apitox, Active Pharmaceutical Ingredient (API) has been studied preclinically. Hyaluronidase, which is approximately 2% percent of the Apitox API improves the transportation of the active Amines, Enzymes and Peptides to the capillaries. The Active Pharmaceutical Ingredient is lyophilized in 3 ml vials for use in clinical trials and commercial use. Apitox is delivered by small 0.01 ml intradermal injections at the treatment site. In an FDA Phase 3 study of Apitox for the reduction of pain and increase in mobility in Osteoarthritis patients. A small amount of lidocaine was added to remove any pain or discomfort at the injection site. The company plans to expand the use of Apitox in other autoimmune diseases.


Amines


• Histamine
• Dopamine


Enzymes


• Hyaluronidase
• Phospholipase


Peptides


• Melittin
• Apamin
• MCD Peptide
• Adolapin
• Protease inhibitor


Bee venom’s analgesic and anti-inflammatory effects as well as its safety has been documented in well controlled, statistically significant clinical studies and used globally for centuries.



Efficacy to be studied in an upcoming

Phase III trials are:


Pain

Pain sensations like burning, stabbing, sharp and squeezing sensations. In MS you can experience acute neuropathic pain and chronic neuropathic pain.




Unstable Gait/Balance

Difficulty in walking — also known as problems with gait —  is among the most common mobility limitations in MS.



Fatigue

MS fatigue is different from regular tiredness. Describe as feeling like you’re weighed down and like every movement is difficult or clumsy.





Bladder Control

Bladder dysfunction, which occurs in at least 80 percent of people with MS, happens when MS lesions block or delay transmission of nerve signals in areas of the central nervous system (CNS) that control the bladder and urinary sphincters.



Weakness

MS patients also experience muscle weakness along with spasticity. Spasticity in MS usually affects the legs more than the arms, and it can even offset muscle weakness and aid in standing, walking, and transferring.



Spasticity

It is one of the more common symptoms of MS. Spasticity may be as mild as the feeling of tightness of muscles or may be so severe as to produce painful, uncontrollable spasms of extremities, usually of the legs.



Corporate
presentation

Corporate Presentation – December 2020
UPLOADED: December 2020
View PDF

Apimeds defers to the two US multiple sclerosis societies for current clinical trials for the disease and suggested treatments in association with experts at centers of excellence in Multiple sclerosis.



Multiple Sclerosis Association of America

375 Kings Highway North
Cherry Hill, New Jersey 08034
(800)532-7667


National Multiple Sclerosis Society

733 Third Avenue 3rd Floor
New York, NY 10017 USA
(212)476-0485


Get in touch

If you want to contact us, call us, send us any correspondence using the online form, or simply email us.


Address

2 East Broad Street
2nd Floor
Hopewell, NJ 08525


Call us

+1(609)751-4485



Contact us


Call us

+1(925)872-6429


Address

2 East Broad Street
2nd Floor
Hopewell, NJ 08525


Send us an email

[email protected]



About us



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    Contact us


    Call us

    +1(609)751-4485


    Address

    Apimeds Pharmaceuticals
    125 Broemel Place. Suite 639
    Pennington, NJ 08534


    Send us an email

    [email protected]



    About us



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      Copyright by Apimeds Pharmaceuticals 2023. All rights reserved.



      Copyright by Apimeds Pharmaceuticals 2023. All rights reserved.